Polynucleotides – The Natural Treatment Helping Skin Rebuild Itself
If you’ve been exploring aesthetic treatments but want to keep things as natural as possible, polynucleotides might be the solution you’ve been searching for.
Often described as a “skin reset,” polynucleotide treatments have gained momentum in the world of regenerative aesthetics because they do more than just hydrate or fill. They actually help your skin repair, rebuild, and strengthen itself over time.
At our Essex clinic, we’re seeing more and more women, especially mums in their 30s and 40s, choosing polynucleotides as a way to support their skin through hormonal changes, postnatal recovery, or early signs of ageing.
So, what exactly are polynucleotides?
Polynucleotides are naturally derived molecules that help repair damaged skin and stimulate fibroblasts—the cells responsible for collagen and elastin production. When injected into the skin, they essentially encourage it to behave like it did when it was younger: firmer, bouncier, and better at healing itself.
Unlike traditional fillers or Botox, polynucleotides don’t “freeze” or “fill” anything. Instead, they quietly enhance the skin’s overall health and structure, making them a great option for clients who want subtle, inside-out results.
They’re especially effective for delicate areas like the under eyes, where volume loss and fine lines can be hard to treat with traditional injectables.
Who is this treatment best for?
You don’t need to have severe skin concerns to benefit from polynucleotides. They’re ideal for women looking to:
Improve skin texture and elasticity
Address early volume loss or fine lines
Rehydrate and brighten tired-looking skin
Support the skin during perimenopause or motherhood hormonal changes
Maintain a youthful look without drastic changes
We often recommend polynucleotides as part of a preventative or restorative plan especially for clients not ready for fillers but looking for visible improvement in how their skin looks and feels.
What results can you expect?
Results aren’t instant—but they’re meaningful. Most clients begin to notice a difference in skin tone and smoothness within a few weeks, with improvements continuing to build over time. A course of 2 to 3 sessions is usually recommended for optimal results.
The final outcome? Skin that looks stronger, firmer and more radiant—without anyone being able to pinpoint exactly what you’ve had done.
How we use them at our clinic
Polynucleotides can be used as a standalone treatment or combined with other advanced skin therapies. For many clients, we layer them into full-face rejuvenation plans alongside:
Microneedling with exosomes, for maximum skin regeneration
Sculptra, to address deeper structural changes
Skin boosters, for hydration and glow
ZO Skin Health, to maintain the results at home
We’ll always tailor your plan based on your skin, your goals and your comfort level.
Feel like yourself—just fresher
If your skin feels tired, dehydrated, or less resilient than it used to, polynucleotides could be the gentle nudge it needs to come back to life.
Book a consultation with us at Piril Sideras Aesthetics, and we’ll help you explore whether this natural, collagen-supporting treatment is right for you.
You don’t need to change your face. Just support your skin and let it do the rest.
